protein–glutamine γ-glutamyltransferase

• transglutaminase
• Factor XIIIa
• fibrinoligase

Protein–glutamine γ-glutamyltransferases catalyse the amide-transferase reaction between the γ-glutamyl group of glutamine residues and the ε-amino group of lysine residues in proteins, resulting in intra-and intermolecular cross-linkings of proteins. In the absence of amino substrates, transglutaminases catalyse the deamidation of glutamyl residues involving water as an acyl acceptor.